University of Connecticut University of UC Title Fallback Connecticut

colonafferents pic_mems mechanic_br

Introduction

 

     Not to confuse with the public radio station, research at NPR is focused upon the sensory encoding and processing of the peripheral nervous system. Particular interests are given on 1) how the sensory afferent neurons detect and transmit pain-related sensory information, 2) the peripheral mechanisms that underlie the sensory aberrations in chronic pain and 3) translating scientific discoveries into next-generation neuromodulatory strategies and devices that target peripheral nerves/neurons for the better management of chronic pain.

     We are focused on but not limited to the study of visceral pain, i.e., pain arising from the internal organs.

visceral_innervate
sensory innervation of the viscera

     We employ a multi-disciplinary approach that includes 1) experimental studies on the sensory nerve endings by in vitro electrophysiology and biomechanics of visceral tissue, 2) state-of-the-art molecular biology and generic knock-out/knock-in mouse models, and 3) computational simulations and rigorous mathematical analysis that integrates the experimental findings to deepen the theoretical understanding of visceral afferent encoding and sensitization. As biomedical engineers, we are also enthusiastic in engineering the next generation tools for neuroscience studies in general and visceral pain management in particular.

NPR News

April 2017: Our undergraduate Kyle Troki has submitted an application to  the Deligeorges Family Scholarship in Bioengineering using his on-going research project. Fingers crossed! 

Mar 2017: Our undergraduate Dhruv Shah has received the $3,300 Summer Undergraduate Research Funds (SURF) from UCONN. Congratulations! 

Feb 2017: Our undergraduate Dhruv Shah is among one of the top 5% applicants to be accepted into the prestigious  Harvard Summer Research Program in Kidney Medicine (HSRPKM). Congratulations! 

Jan 2017: Longtu's Manuscript " Pharmacological approach for managing pain in irritable bowel syndrome; a review article" is now accepted for publication in Anesthesiology and Pain Medicine.

Jan 2017: Our study grant with Allergan Inc. has been extended to Dec 2017.

Oct 2016: Dr. Feng and Dr. Santaniello from UConn BME hosted the 20th Annual Neuroscience at Storrs mini symposium.

Oct 2016: NPR student Longtu and Dr. Feng attended the BMES 2016 (Minneapolis, MN) and gave a poster presentation entitled “In Vitro Multichannel Single-unit Recordings of Action Potentials from Mouse Sciatic Nerve.”

Sept 2016: Dr. Lucas at the School of Nursing together with Dr. Feng are recipients of the CT Bio Pipline grant ($30,000) for their project titled "A low cost portable device for breastfeeding diagnostic". 

Aug 2016: Dr. Feng received a study grant ($93,791) from Allergan Inc. to investigate the role of Eluxadoline in treating IBS-related visceral pain.