Refereed Journal Articles
*Corresponding author
Full list of Dr. Feng’s journal publications at
- Gan RZ, Feng B, Sun Q. Three-dimensional finite element modeling of human ear for sound transmission. Ann Biomed Eng. 2004;32(6):847-59.
- Feng B, Gan RZ. Lumped parametric model of the human ear for sound transmission. Biomech Model Mechanobiol. 2004;3(1):33-47.
- Gan RZ, Sun Q, Feng B, Wood MW. Acoustic-structural coupled finite element analysis for sound transmission in human ear–pressure distributions. MedEng Phys. 2006;28(5):395-404.
- Feng B, Li BY, Nauman EA, Schild JH. Theoretical and electrophysiological evidence for axial loading about aortic baroreceptor nerve terminals in rats. Am J Physiol Heart Circ Physiol. 2007;293(6):H3659-72.
- Li BY, Feng B, Tsu HY, Schild JH. Unmyelinated visceral afferents exhibit frequency dependent action potential broadening while myelinated visceral afferents do not. Neurosci Lett. 2007;421(1):62-6.
- Wladyka CL, Feng B, Glazebrook PA, Schild JH, Kunze DL. The KCNQ/M-current modulates arterial baroreceptor function at the sensory terminal in rats. J Physiol. 2008;586(3):795-802.
- Li BY, Qiao GF, Feng B, Zhao RB, Lu YJ, Schild JH. Electrophysiological and neuroanatomical evidence of sexual dimorphism in aortic baroreceptor and vagal afferents in rat. Am J Physiol Regul Integr Comp Physiol. 2008;295(4):R1301-10.
- Brumovsky PR, Feng B, Xu L, McCarthy CJ, Gebhart GF. Cystitis increases colorectal afferent sensitivity in the mouse. American journal of physiology Gastrointestinal and liver physiology. 2009;297(6):G1250-8.
- Shinoda M, Feng B, Gebhart GF. Peripheral and central P2X receptor contributions to colon mechanosensitivity and hypersensitivity in the mouse. Gastroenterology. 2009;137(6):2096-104.
- Feng B, Brumovsky PR, Gebhart GF. Differential roles of stretch-sensitive pelvic nerve afferents innervating mouse distal colon and rectum. American journal of physiology Gastrointestinal and liver physiology. 2010;298(3):G402-9.
- Feng B, Gebhart GF. Characterization of silent afferents in the pelvic and splanchnic innervations of the mouse colorectum. American journal of physiology Gastrointestinal and liver physiology. 2011;300(1):G170-80.
- Tanaka T, Shinoda M, Feng B, Albers KM, Gebhart GF. Modulation of visceral hypersensitivity by glial cell line-derived neurotrophic factor family receptor α-3 in colorectal afferents. American journal of physiology Gastrointestinal and liver physiology. 2011;300(3):G418-24.
- Feng B, La JH, Schwartz ES, Tanaka T, McMurray TP, Gebhart GF. Long-term sensitization of mechanosensitive and -insensitive afferents in mice with persistent colorectal hypersensitivity. American journal of physiology Gastrointestinal and liver physiology. 2012;302(7):G676-83.
- Feng B, La JH, Schwartz ES, Gebhart GF. Irritable bowel syndrome: methods, mechanisms, and pathophysiology. Neural and neuro-immune mechanisms of visceral hypersensitivity in irritable bowel syndrome. American journal of physiology Gastrointestinal and liver physiology. 2012;302(10):G1085-98.
- Feng B, La JH, Tanaka T, Schwartz ES, McMurray TP, Gebhart GF. Altered colorectal afferent function associated with TNBS-induced visceral hypersensitivity in mice. American journal of physiology Gastrointestinal and liver physiology. 2012;303(7):G817-24.
- La JH, Feng B, Schwartz ES, Brumovsky PR, Gebhart GF. Luminal hypertonicity and acidity modulate colorectal afferents and induce persistent visceral hypersensitivity. American journal of physiology Gastrointestinal and liver physiology. 2012;303(7):G802-9.
- Feng B, Kiyatkin ME, La J-H, Ge P, Solinga R, Silos-Santiago I, Gebhart GF. Activation of Guanylate Cyclase-C Attenuates Stretch Responses and Sensitization of Mouse Colorectal Afferents. The Journal of Neuroscience. 2013;33(23):9831-9.
- Kiyatkin ME, Feng B, Schwartz ES, Gebhart GF. Combined genetic and pharmacological inhibition of TRPV1 and P2X3 attenuates colorectal hypersensitivity and afferent sensitization. American journal of physiology Gastrointestinal and liver physiology. 2013;305(9):G638-48.
- Feng B, Gebhart GF. In vitro functional characterization of mouse colorectal afferent endings. J Vis Exp. 2015(95):52310.
- Feng B, Zhu Y, La JH, Wills ZP, Gebhart GF. Experimental and computational evidence for an essential role of NaV1.6 in spike initiation at stretch-sensitive colorectal afferent endings. J Neurophysiol. 2015;113(7):2618-34.
- Zhu Y, Feng B, Schwartz ES, Gebhart GF, Prescott SA. Novel method to assess axonal excitability using channelrhodopsin-based photoactivation. J Neurophysiol. 2015;113(7):2242-9.
- Shaffer AD, Feng B, La JH, Joyce SC, Gebhart GF. A novel role for follistatin in hypersensitivity following cystitis. Neurourol Urodyn. 2015.
- La JH, Feng B, Kaji K, Schwartz ES, Gebhart GF. Roles of isolectin B4-binding afferents in colorectal mechanical nociception. Pain. 2016;157(2):348-54.
- Feng B, Joyce SC, Gebhart GF. Optogenetic activation of mechanically insensitive afferents in mouse colorectum reveals chemosensitivity. American journal of physiology Gastrointestinal and liver physiology. 2016;310(10):G790-8.
- Schwartz ES, La JH, Young EE, Feng B, Joyce S, Gebhart GF. Chronic Prostatitis Induces Bladder Hypersensitivity and Sensitizes Bladder Afferents in the Mouse. J Urol. 2016;196(3):892-901.
- Chen L, Ilham SJ, Guo T, Emadi S, Feng B. In vitro multichannel single-unit recordings of action potentials from mouse sciatic nerve. Biomed Phys Eng Express. 2017;3(4):045020.
- Chen L, Ilham SJ, Feng B. Pharmacological Approach for Managing Pain in Irritable Bowel Syndrome: A Review Article. Anesth Pain Med. 2017;7(2):e42747.
- Chen L, Lucas RF, Feng B. A Novel System to Measure Infants’ Nutritive Sucking During Breastfeeding: the Breastfeeding Diagnostic Device (BDD). IEEE J Transl Eng Health Med. 2018;6:2700208.
- Ilham SJ, Chen L, Guo T, Emadi S, Hoshino K, Feng B. In vitro single-unit recordings reveal increased peripheral nerve conduction velocity by focused pulsed ultrasound. Biomed Phys Eng Express. 2018;4(4):045004.
- Makadia PA, Najjar SA, Saloman JL, Adelman P, Feng B, Margiotta JF, Albers KM, Davis BM. Optogenetic activation of colon epithelium of the mouse produces high-frequency bursting in extrinsic colon afferents and engages visceromotor responses. Journal of Neuroscience. 2018;38(25):5788-98.
- Feng B, Chen L, Ilham SJ. A Review on Ultrasonic Neuromodulation of the Peripheral Nervous System: Enhanced or Suppressed Activities? Applied Sciences. 2019;9(8):1637.
- Guo T, Bian Z, Trocki K, Chen L, Zheng G, Feng B. Optical recording reveals topological distribution of functionally classified colorectal afferent neurons in intact lumbosacral DRG. Physiological Reports. 2019;7(9):e14097.
- Siri S, Maier F, Chen L, Santos S, Pierce DM, Feng B. Differential biomechanical properties of mouse distal colon and rectum innervated by the splanchnic and pelvic afferents. American journal of physiology Gastrointestinal and liver physiology. 2019;316(4):G473-G81.
- Siri S, Maier F, Santos S, Pierce DM, Feng B. Load-bearing function of the colorectal submucosa and its relevance to visceral nociception elicited by mechanical stretch. American journal of physiology Gastrointestinal and liver physiology. 2019;317(3):G349-G58.
- Feng B. New insights on expression and function of Mu and delta opioid receptors in mouse gastrointestinal tract. Cellular and Molecular Gastroenterology and Hepatology. 2020;9(3):553-4.
- Siri S, Zhao Y, Maier F, Pierce DM, Feng B. The Macro- and Micro-Mechanics of the Colon and Rectum I: Experimental Evidence. Bioengineering. 2020;7(4):130.
- Zhao Y, Siri S, Feng B, Pierce DM. The Macro-and Micro-Mechanics of the Colon and Rectum II: Theoretical and Computational Methods. Bioengineering. 2020;7(4):152.
- Zhao Y, Feng B, Lee J, Lu N, Pierce D. A multi-layered model of human skin elucidates mechanisms of wrinkling in the forehead. Journal of the Mechanical Behavior of Biomedical Materials. 2020;105:103694.
- Sadeghi Najafabadi M, Chen L, Dutta K, Norris A, Feng B, Schnupp JWH, Rosskothen-Kuhl N, Read HL, Escabi MA. Optimal Multichannel Artifact Prediction and Removal for Neural Stimulation and Brain Machine Interfaces. Front Neurosci. [Methods]. 2020;14(709):709.
- Zhao Y, Feng B, Lee J, Lu N, Pierce DM. A multi-layered computational model for wrinkling of human skin predicts aging effects. Journal of the Mechanical Behavior of Biomedical Materials. 2020;103:103552.
- Feng B, Guo T. Visceral pain from colon and rectum: the mechanotransduction and biomechanics. Journal of Neural Transmission. 2020;127(4):415-29.
- Guo T, Chen L, Tran K, Ghelich P, Guo Y-S, Nolta N, Emadi S, Han M, Feng B. Extracellular single-unit recordings from peripheral nerve axons in vitro by a novel multichannel microelectrode array. Sensors and Actuators B: Chemical. 2020;315:128111.
- Posada-Quintero HF, Kong Y, Nguyen K, Tran C, Beardslee L, Chen L, Guo T, Cong X, Feng B, Chon KH. Using electrodermal activity to validate multilevel pain stimulation in healthy volunteers evoked by thermal grills. Am J Physiol Regul Integr Comp Physiol. 2020;319(3):R366-R75.
- Guo T, Patel S, Shah D, Chi L, Emadi S, Pierce DM, Han M, Brumovsky PR, Feng B. Optical clearing reveals TNBS-induced morphological changes of VGLUT2-positive nerve fibers in mouse colorectum. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2021;320(4):G644-G57.
- Song P, Guo C, Jiang S, Wang T, Hu P, Hu D, Zhang Z, Feng B, Zheng G. Optofluidic ptychography on a chip. Lab on a Chip. 2021;21(23):4549-56.
- Zhao Y, Siri S, Feng B, Pierce DM. Toward Elucidating the Physiological Impacts of Residual Stresses in the Colorectum. Journal of Biomechanical Engineering. 2021;144(1):011008.
- Bian Z, Guo T, Jiang S, Chen L, Liu J, Zheng G, Feng B. High-Throughput Functional Characterization of Visceral Afferents by Optical Recordings From Thoracolumbar and Lumbosacral Dorsal Root Ganglia. Frontiers in Neuroscience. [Original Research]. 2021;15(254).
- Maier F, Siri S, Santos S, Chen L, Feng B, Pierce DM. The heterogeneous morphology of networked collagen in distal colon and rectum of mice quantified via nonlinear microscopy. Journal of the Mechanical Behavior of Biomedical Materials. 2021;113:104116.
- Zhao Y, Siri S, Feng B, Pierce DM. Computational Modeling of Mouse Colorectum Capturing Longitudinal and Through-thickness Biomechanical Heterogeneity. Journal of the Mechanical Behavior of Biomedical Materials. 2021;113:104127.
- Liu J, Ganeshbabu N, Shalaby N, Chen L, Guo T, Feng B. Targeting Two-Pore-Domain Potassium Channels by Mechanical Stretch Instantaneously Modulates Action Potential Transmission in Mouse Sciatic Nerves. ACS Chemical Neuroscience. 2021;12(19):3558-66.
- Jiang S, Guo C, Song P, Zhou N, Bian Z, Zhu J, Wang R, Dong P, Zhang Z, Liao J, Yao J, Feng B, Murphy M, Zheng G. Resolution-Enhanced Parallel Coded Ptychography for High-Throughput Optical Imaging. ACS Photonics. 2021;8(11):3261-71.
- Chen J, Barandouzi ZA, Lee J, Xu W, Feng B, Starkweather A, Cong X. Psychosocial and sensory factors contribute to self-reported pain and quality of life in young adults with irritable bowel syndrome. Pain Management Nursing. 2022.
- Chen J, Zhang Y, Barandouzi ZA, Xu W, Feng B, Chon K, Santos M, Starkweather A, Cong X. Somatosensory Profiles Differentiate Pain and Psychophysiological Symptoms Among Young Adults With Irritable Bowel Syndrome: A Cluster Analysis. The Clinical Journal of Pain. 2022;38(7).
- Chen J, Zhang Y, Barandouzi ZA, Lee J, Zhao T, Xu W, Chen M-H, Feng B, Starkweather A, Cong X. The effect of self-management online modules plus nurse-led support on pain and quality of life among young adults with irritable bowel syndrome: A randomized controlled trial. International journal of nursing studies. 2022;132:104278.
- Chen L, Guo T, Zhang S, Smith PP, Feng B. Blocking peripheral drive from colorectal afferents by subkilohertz dorsal root ganglion stimulation. PAIN. 2022;163(4):665-81.
- Jiang S, Guo C, Wang T, Liu J, Song P, Zhang T, Wang R, Feng B, Zheng G. Blood-Coated Sensor for High-Throughput Ptychographic Cytometry on a Blu-ray Disc. ACS sensors. 2022;7(4):1058-67.
- Zhao Y, Feng B, Pierce D. Predicting the micromechanics of embedded nerve fibers using a novel three-layered model of mouse distal colon and rectum. Journal of the Mechanical Behavior of Biomedical Materials. 2022:105083.
- Feng B, Malykhina AP. Editorial: Emerging trends in abdominal and pelvic pain. Front Pain Res (Lausanne). 2023;4:1254682.
- Jiang S, Song P, Wang T, Yang L, Wang R, Guo C, Feng B, Maiden A, Zheng G. Spatial-and Fourier-domain ptychography for high-throughput bio-imaging. Nature protocols. 2023;18(7):2051-83.
- Zhang S, Chen L, Feng B. An anesthesia protocol for robust and repeatable measurement of behavioral visceromotor responses to colorectal distension in mice. Front Pain Res (Lausanne). 2023;4:1202590.
- Ryu J, Qiang Y, Chen L, Li G, Han X, Woon E, Bai T, Qi Y, Zhang S, Liou Jy. Multifunctional Nanomesh Enables Cellular‐Resolution, Elastic Neuroelectronics. Advanced Materials. 2024:2403141.
- Song P, Wang R, Loetgering L, Liu J, Vouras P, Lee Y, Jiang S, Feng B, Maiden A, Yang C, Zheng G. Ptycho-endoscopy on a lensless ultrathin fiber bundle tip. Light: Science & Applications. 2024.
- Zhang S, Chen L, Ladez SR, Seferge A, Liu J, Feng B. Blocking Aδ-and C-fiber neural transmission by sub-kilohertz peripheral nerve stimulation. Frontiers in Neuroscience. 2024;18:1404903.
- Zhang S, Chen L, Woon E, Liu J, Ryu JH, Fang H, Feng B. Suppression of Visceral Nociception by Selective C-Fiber Transmission Block Using Temporal Interference Sinusoidal Stimulation. BioRxiv. 2024; https://doi.org/10.1101/2024.10.13.618090.
- Kader L, Willits A, Meriano S, Christianson JA, La J-H, Feng B, Knight B, Kosova G, Deberry J, Coates M, Hyams J, Baumbauer K, Young EE. Identification of arginine-vasopressin receptor 1a (Avpr1a/AVPR1A) as a novel candidate gene for chronic visceral pain sheds light on the potential role of enteric neurons in the development of visceral hypersensitivity. The Journal of Pain. 2024:104572.
- Shokrani A, Almasi A, Feng B, Pierce DM. Understanding mechanotransduction in the distal colon and rectum via multiscale and multimodal computational modeling. J Mech Behav Biomed Mater. 2024;160:106771.
- Guo T, Liu J, Chen L, Bian Z, Zheng G, Feng B. Sex differences in zymosan-induced behavioral visceral hypersensitivity and colorectal afferent sensitization. American journal of physiology Gastrointestinal and liver physiology. 2024;326(2):G133-G46.
- Liu J, Zhang S, Emadi S, Guo T, Chen L, Feng B. Morphological, molecular, and functional characterization of mouse glutamatergic myenteric neurons. American journal of physiology Gastrointestinal and liver physiology. 2024;326(3):G279-G90.
- McNaboe RQ, Kong Y, Henderson WA, Cong X, Li A, Seo M-H, Chen M-H, Feng B, Posada-Quintero HF. Optimizing Sensor Locations for Electrodermal Activity Monitoring Using a Wearable Belt System. Journal of Sensor and Actuator Networks. 2025;14(2):31.
- Woon E, Zhang S, Chen L, Kuchel G, Bartley J, Feng B (2024) bladder Integrated Assessment of Continuous Uroflow Cystometry and Visceromotor Responses to Bladder Distension in Urethane-Anesthetized Mice. Journal of Pharmacology and Experimental Therapeutics. JPET-AR-2024-002332. (in 2nd review)
- Ostertag-Hill CA, Chen S, Xue T, Shao R, Torre M, Feng B, Vahedi Z, Chen L, Zheng Y, Kohan DS (2024) Safe sensory-selective peripheral and neuraxial nerve blockade with 2′,6′-pipecolylxylidine. (under review).
- Shokrani A, Seck A, Feng B, Pierce DM (2024) Methods for Quantitative Analyses of Nerve Fiber Deformation in the Myenteric Plexus Under Loading of Mouse Distal Colon and Rectum. Journal of the Mechanical Behavior of Biomedical Materials. Under review. JMBBM-S-24-01470. (in 2nd review)
- Sanyukta A Patil, Longtu Chen, Christopher Foster, Yuhang Xiao, Feng B, Courtney K Rowe, and Kelly A Burke (2025) Brush-Like Polymer Surface on Silk Fibroin Films for Controlled Release of Local Anesthetic. (under review).
- Woon E, Santeli J, Liu J, Chen L, Kuchel G, Feng B. Pharmacological Targeting of Hyperpolarization-activated Cyclic Nucleotide-gated Cation Channels on Bladder Afferent Neural Encoding, LUTS: Lower Urinary Tract Symptoms. (under review)
Book Chapters
- Feng B, Gebhart GF. Visceral mechanoreceptors. In Encyclopedia of Pain, 2nd, (Schmidt RF and Gebhart GF, Eds.), Springer-Verlag, Berlin, Heidelberg, 2013; 4170-4174. DOI: 10.1007/978-3-642-28753-4_4906
- Gebhart GF, Feng B. Sensitization of visceral nociceptors. In Encyclopedia of Pain, 2nd, (Schmidt RF and Gebhart GF, Eds.), Springer-Verlag, Berlin, Heidelberg, 2013; 3464-3468.
- Feng B, Pierce DM. The biomechanics of distal colon and rectum and its relevance to visceral pain. In Visceral Pain, (Brierley SM and Spencer NJ, Eds.), Springer- Cham, 2023; 81-103. DOI: 1007/978-3-031-25702-5_7
- Gebhart GF, Feng B. Interstitial Cystitis / Bladder Pain Syndrome. In Incontinence 7th Ed., (Cardozo L, Rovner E, Wagg A, Wein A and Abrams P, Eds). ICI-ICS. International Continence Society, Bristol UK, ISBN: 978-0-9569607-4-0. https://www.ics.org/ici
- Feng B. Chronic pain as a neurological disease and its management with neural engineering approaches. In Handbook of Neural Engineering: A Modern Approach, (Stephanie Willerth, Ed). Elsevier, 2024.
Invited talks
- “Electrical and Mechanical Behaviors of Rat Aortic Baroreceptors – Computational modeling and in vitro experimental study,” Summer Seminar Series, Purdue University, Weldon School of Biomedical Engineering. West Lafayette, IN, July 18, 2005.
- “Electrical and Mechanical Behaviors of Rat Aortic Baroreceptors,” University of California, Department of Anesthesiology, Los Angeles, CA, Department of, Nov 30, 2007.
- “Electrical and Mechanical Behaviors of Rat Aortic Baroreceptors,” Northwestern University, Department of Neurobiology, Evanston, IL. May 9, 2008.
- “Silent Afferents and Visceral Hypersensitivity,” Neuron @ Noon seminar, University of Pittsburgh, Department of Neurobiology, Pittsburgh, PA, April 13, 2010.
- “Sherrington’s Last Stand: Did the Term “Nociceptor” Outlive Its Utility?” 30th Annual Scientific Meeting of the American Pain Society, Austin, TX, May 19, 2011.
- “Visceral Pain and Management: a Neuronal and Biomechanical Approach,” University of Connecticut, Biomedical Engineering Department, Storrs, CT, May 14, 2014.
- “Visceral Pain and Management: a Neural Engineering and Neuromodulation Approach,” BME Seminar Series, University of Connecticut, Storrs, CT, Sept 11, 2015.
- “Computational Modeling of Neural Excitability at Colorectal Afferent Endings and Somata,” Biomedical Engineering Society 2015 Annual Fall Meeting, Tampa, FL, Oct 10, 2015.
- “Visceral Pain and Hypersensitivity, an Experimental and Computational Approach,” Queen Mary University, Wingate Institute of Neurogastroenterology, London, UK, Dec 5, 2016.
- “Role of Afferent Sensitization in Visceral Pain and Hypersensitivity,” University of Alabama, Department of Anesthesiology and Perioperative Medicine, Birmingham, AL, April 4, 2017.
- “Visceral Pain: The Physiology,” 2019 North American Neuromodulation Society (NANS) Annual Meeting, Las Vegas, NV, Jan 19, 2019.
- “Visceral Pain: The Psychophysical Features and Physiology,” 11th Congress of the International Society for Autonomic Neuroscience (ISAN 2019), Los Angeles, CA, July 27, 2019.
- “Visceral Pain: The Physiology and Management,” 3rd CAMP annual pain symposium, University of Connecticut, CT, Nov 1, 2019.
- “Visceral Pain: The Physiology and Management,” Drexel University, School of Biomedical Engineering, Philadelphia, PA, Nov 20, 2019.
- “Understanding neuromodulation to enhance management of visceral pain,” Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, Mar 3, 2020.
- “The Biomechanics and Mechanotransduction in Visceral Nociception,” 4th Federation of Neurogastroenterology and Motility (FNM) meeting, Adelaide, Australia, Mar 29, 2020 (Moved to online due to COVID-19).
*Focused gathering of visceral pain researchers all over the world.
- “Understanding DRG stimulation to enhance management of visceral pain,” 2nd Biomedical Engineering and Instrumentation Summit” (BEIS-2020), Boston, MA, July 22, 2020 (Rescheduled to April 21, 2021 due to COVID-19).
- “Visceral pain and management: the neurophysiology, biomechanics, and neuromodulation,” School of Medicine, Austral University, Argentina, July 7, 2021.
- “Understanding DRG stimulation to enhance management of visceral pain,” Pain 2022 Workshop, sponsored by the Rita Allen Foundation, Feb 18, 2022.
- “Visceral pain and management: the neurophysiology, biomechanics, and neuromodulation,” Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, Mar 21, 2022
- “Lumbosacral DRG Neuromodulation for Treating Colorectal and Pelvic Pain,” AUA 2023, American Urological Association, Chicago, IL, April 28, 2023.
- “Chronic Pain from Deep Tissues: Physiological Insights and Treatment Strategies,” ICHST-2023, The 1st International Conference on Health Science and Technology, Hanoi, Vietnam, Dec 28, 2024
- “Targeting the Dorsal Root Ganglion: Combined Na,K-ATPase Antagonist and Electrical Stimulation for Chronic Pain Management”, 6th International Conference on Pharmscience Research & Development, Boston, MA, Feb 27, 2024
- “Chronic pain and management: combined pharmacological and neuromodulation approach”, Department of Chemistry, Chemical and Biomedical Engineering, University of New Haven, CT, Jan 24th, 2025
- “Computational Modeling in Pain Research: Identifying Novel Targets for Chronic Pain”, Math in the (Neuro)Sciences Workshop, University of Connecticut, CT, Mar 8th, 2025